F. Bianchi

Selective Impact of ALK and MELK Inhibition on ERα Stability and Cell Proliferation in Cell Lines Representing Distinct Molecular Phenotypes of Breast Cancer

This study identifies ALK and MELK inhibition as potential targets for specific breast cancer subtypes by showing their impact on ER stability and proliferation.

Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

This study identifies FOXM1 as a microenvironment-induced factor that sustains ovarian cancer stemness and enhances response to Olaparib.

Trafficking Machinery is Rapidly Primed to Facilitate Polarised IL-6 Secretion in Dendritic Cells

This study shows that LPS rapidly primes trafficking machinery in dendritic cells to enhance polarized IL-6 secretion through phosphorylation of VAMP3.

Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration through the Extracellular Matrix

This study shows that cofilin-1 phosphorylation drives nuclear deformation and enhances dendritic cell migration through extracellular matrix.

Leveraging medical Twitter to build a visual-language foundation model for pathology AI

The paper builds a visual-language foundation model for pathology AI using a large dataset of pathology images and natural language descriptions curated from medical Twitter.

Matrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancer

This study identifies Matrix Gla Protein (MGP) as a driver of stemness and tumor initiation in ovarian cancer by promoting Hedgehog signaling and enhancing tumor-initiating capacity.

A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

The paper identifies a MYO6-DOCK7-RAC1 axis that restricts RAC1 activity in a planar polarized manner to drive tissue fluidification and collective motion in carcinoma cell monolayers.

miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

The paper identifies a miR-455-5p/PD-L1 axis that drives chemotherapy resistance in lung cancer metastases and predicts neoadjuvant chemotherapy response.

Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-Cell Acute Lymphoblastic Leukemia

The paper identifies NOTCH1-dependent microRNAs in extracellular vesicles that promote T-ALL cell proliferation and survival by modulating oncogenic pathways.

T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

This study shows that T-cell cholesterol efflux via ABCA1/ABCG1 suppresses apoptosis and senescence, but paradoxically reduces atherosclerosis in middle-aged mice.

Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class I and II epitopes

The paper shows that transmembrane helices are a conserved source of MHC-I and II epitopes, leading to over-presentation of membrane protein-derived peptides in immune responses.

In silico screening for ERα downmodulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells

The paper identifies thioridazine as an anti-proliferative agent effective against ERα-expressing breast cancer cells resistant to tamoxifen.