IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
R. C. Fleith, H. V. Mears, E. Emmott, S. C. Graham, D. S. Mansur, T. R. Sweeney
This study identifies how IFIT3 and IFIT2 enhance IFIT1's ability to inhibit translation by stabilizing its binding to non-self RNA.
bioRxiv · Feb 8, 2018Immunology