E. Emmott

Porcine sapovirus protease controls the innate immune response and targets TBK1

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

Emergence of new subgenomic mRNAs in SARS-CoV-2

This study identifies new subgenomic mRNAs in SARS-CoV-2 arising from mutations that create novel transcription regulatory sequences, leading to the expression of functional proteins like N.iORF3.

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

The paper introduces pSCoPE, a single-cell proteomics method that improves sensitivity, completeness, and depth, enabling analysis of protein variation in macrophages.

Multiplexed single-cell proteomics using SCoPE2

The paper introduces SCoPE2, a multiplexed single-cell proteomics method that enables quantitative analysis of over 1,000 proteins per cell using standard equipment.

The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus.

This study determines the cryo-EM structure of vesivirus 2117, revealing structural differences in the capsid that suggest variations in entry pathways among vesivirus clades.

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.

Herpes simplex virus-1 pUL56 degrades GOPC to alter the plasma membrane proteome

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.

This study shows Ifit1 enhances the interferon response but does not directly inhibit norovirus translation in murine macrophage-like cells.

Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.

This study identifies G3BP1 as a host factor essential for norovirus infection and reveals its role in VPg-dependent translation initiation.

IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.

This study identifies how IFIT3 and IFIT2 enhance IFIT1's ability to inhibit translation by stabilizing its binding to non-self RNA.

Spatial and temporal control of norovirus protease activity is determined by polyprotein processing and intermolecular interactions within the viral replication complex.

This study investigates how norovirus protease activity is regulated by polyprotein processing and intermolecular interactions within the replication complex, showing that precursor forms are active in vitro but their activity in cells depends on localization and substrate access.

VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction

This study identifies a RING-RING interaction between VPS18 and VPS41 that recruits VPS41 to the human HOPS complex, showing this mechanism is not conserved in yeast.