Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids
L. W. Rodenburg, L. Delpiano, V. Railean, R. Centeio, M. C. Pinto, S. M. A. Smits, I. S. van der Windt, C. F. J. van Hugten, S. F. B. van Beuningen, R. N. P. Rodenburg, C. K. van der Ent, M. D. Amaral, K. Kunzelmann, M. A. Gray, J. M. Beekman, G. D. Amatngalim
This study identifies 12 FDA-approved drugs that induce CFTR-independent fluid secretion in nasal organoids, offering potential treatment for CF patients unresponsive to CFTR modulators.
bioRxiv · Sep 23, 2022Cell Biology