R. Cheloha

Highly biased agonism for GPCR ligands via nanobody tethering

The paper describes a method to create highly biased agonists for GPCRs by tethering a peptide ligand to a nanobody, achieving pathway selectivity without altering the core ligand structure.

Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1

This study shows that conjugating nanobodies with NK1R ligands creates compounds with distinct signaling properties and enhanced transcriptional outputs.