S. Sachdev

Highly biased agonism for GPCR ligands via nanobody tethering

The paper describes a method to create highly biased agonists for GPCRs by tethering a peptide ligand to a nanobody, achieving pathway selectivity without altering the core ligand structure.

Characterization of a nanobody-epitope tag interaction and its application for receptor engineering

The paper characterizes a nanobody-epitope interaction and uses it to enhance ligand potency at an engineered adenosine A2A receptor.

Differential activation of G protein-mediated signalling by synthetic cannabinoid receptor agonists

This study compares how synthetic cannabinoid receptor agonists activate Gs and Gi/o proteins, finding differences in their potency and rank order for cAMP stimulation and inhibition.

Absence of entourage: Terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1 and CB2 receptors

This study tests whether common Cannabis terpenoids modulate CB1 and CB2 receptor activity in vitro, finding no significant effect on receptor signaling or desensitization.

Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells

This paper investigates whether brodifacoum affects cannabinoid receptor function in cells and finds it does not modulate receptor-mediated hyperpolarization or adenylyl cyclase inhibition.

In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids

This study evaluates the efficacy of 13 synthetic cannabinoids at the CB1 receptor using receptor depletion and operational model fitting, finding most have higher efficacy than Δ9-THC.