Obesity-driven changes in ECM composition promote local invasion and metastasis of breast tumors
A. Wishart, Y. Peng, S. Conner, J. Guarin, R. Crews, J. Fatherree, A. S. Greenberg, M. J. Oudin
This study shows obesity alters ECM composition in mammary tissue, promoting breast cancer invasion and metastasis through Collagen VI and EGFR signaling.
bioRxiv · Jan 29, 2020 · PreprintCancer Biology