Proximity Labeling to Map Host-Pathogen Interactions at the Membrane of a Bacteria Containing Vacuole in Chlamydia trachomatis Infected Human Cells
M. G. Olson, R. E. Widner, L. M. Jorgenson, A. Lawrence, D. Lagundzin, N. T. Woods, S. P. Ouellette, E. A. Rucks
The paper uses APEX2 proximity labeling to identify Inc-Inc and Inc-host interactions at the chlamydial inclusion membrane in C. trachomatis infected human cells, revealing LRRF1 as a host protein interacting with multiple Incs.
bioRxiv · Apr 23, 2019Microbiology