S. P. Ouellette

This study investigates FLI1 localization to the chlamydial inclusion and identifies multiple recruitment mechanisms independent of LRRF1.

This study identifies the regulons of two alternative sigma factors in Chlamydia trachomatis by using CRISPR interference and RNA sequencing, showing their essential roles in late-stage development.

This study uses CRISPRi to knock down topA in Chlamydia trachomatis, showing its critical role in developmental cycle and growth.

This study characterizes the ClpC AAA+ ATPase of Chlamydia trachomatis using in vitro and in vivo approaches, revealing its essential role in chlamydial growth and identifying it as a potential target for anti-chlamydial agents.

The paper shows that YtgR represses trpBA expression in Chlamydia trachomatis by sensing both iron and tryptophan levels, using a rare triple-tryptophan motif to regulate transcription termination.

This study shows that ClpX and ClpP2 are essential for Chlamydia trachomatis growth and differentiation, with distinct roles in developmental cycle progression.

This study identifies BacACT, a bactofilin in Chlamydia trachomatis, which forms a dynamic ring structure critical for maintaining cell size and shape during replication.

This paper identifies the unique N-terminal region of Chlamydia MreB as critical for its membrane association and interaction with divisome components, supporting its role as a substitute for FtsZ in cell division.

This study shows that tRNA synthetase inhibitors induce chlamydial persistence independently of IFN-gamma by mimicking amino acid starvation.

The paper uses APEX2 proximity labeling to identify Inc-Inc and Inc-host interactions at the chlamydial inclusion membrane in C. trachomatis infected human cells, revealing LRRF1 as a host protein interacting with multiple Incs.

This paper characterizes two ClpP paralogs in Chlamydia trachomatis, finding they have distinct expression, interaction, and proteolytic activity patterns.