Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model
H. V. Han, R. Efem, B. Rosati, K. Lu, S. Maimouni, Y.-P. Jiang, V. Montoya, A. Van Der Velden, W.-X. Zong, R. Z. Lin
This study identifies Pccb as a regulator of anti-tumor T cell activity in pancreatic cancer, showing that its deletion impairs T cell function and that PD-L1/PD1 blockade can restore T cell activity.
bioRxiv · Jul 24, 2023Cancer Biology