Author

R. Lahesmaa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

O. Rasool· 4 shared T. Buchacher· 4 shared R. Moulder· 3 shared S. D. Bhosale· 3 shared A. Shetty· 2 shared M. M. Khan· 2 shared R. Biradar· 2 shared S. B. A. Andrabi· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersImmunology

O. Rasool

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Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 15, 2023

HIC1 interacts with FOXP3 multi-protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function

S. B. A. Andrabi, K. Batkulwar, S. D. Bhosale…·R. Lahesmaa

This study identifies HIC1 as part of a FOXP3-RUNX1-CBFB complex that regulates Treg cell differentiation and function through interactions with the RUNX1 promoter.

DOI 10.1101/2023.05.15.540505

humanChIP-seq

ImmunologybioRxivMay 12, 2021

Mapping Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells

A. Shetty, S. D. Bhosale, S. K. Tripathi…·R. Lahesmaa

The paper identifies novel protein interaction networks of FOSL1 and FOSL2 in human Th17 cells using affinity purification-mass spectrometry, revealing new mechanistic links to RNA binding and Th17 cell differentiation.

DOI 10.1021/acsomega.1c03681

humanproteomics

ImmunologybioRxivPreprintApr 26, 2021

The AP-1 factors FOSL1 and FOSL2 co-regulate human Th17 responses

A. Shetty, S. K. Tripathi, S. Junttila…·R. Lahesmaa

The paper investigates the roles of FOSL1 and FOSL2 in human Th17 cell differentiation and finds they inhibit Th17 identity and interact with BATF to regulate gene expression.

DOI 10.1101/2021.04.26.441472

humanDNA methylation

ImmunologybioRxivPreprintJan 29, 2021

Quantitative analysis and genome-scale modeling of human CD4+ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

P. Sen, S. B. A. Andrabi, T. Buchacher…·M. Oresic

This study uses genome-scale modeling and lipidomics to show that glycosphingolipid pathways are specifically regulated in Th17 cells during differentiation and are critical for their effector functions.

DOI 10.1101/2021.01.29.428853

humanbulk RNA-seq