P. Sen

Loss of H3K9 trimethylation leads to premature aging

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

Dicarbonyl stress enhances tumor intravasation

This study shows dicarbonyl stress increases cancer cell intravasation by degrading ECM and promoting endothelial dysfunction in a microfluidic model.

Dicarbonyl stress debilitates mesothelial defense against metastasizing ovarian cancer

This study shows dicarbonyl stress weakens mesothelial barriers, enabling ovarian cancer metastasis, and identifies GLO-1 as a potential therapeutic target.

G-Quadruplex Mediated c-myc Specific Downregulation: A Unique Pathway of the Anticancer Action of Immunomodulator Drugs

This study shows that HCQ and CQ downregulate c-myc oncogene transcription via G4 stabilization, reducing tumor growth and enhancing chemotherapy in breast cancer models.

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

Synonymous and non-synonymous transitions/transversions vividly disclose purifying selection in Escherichia coli coding sequences

The paper develops a method to estimate the ti/tv ratio in E. coli coding sequences by accounting for codon degeneracy and pretermination codons, revealing insights into purifying selection.

The transcribed intergenic regions exhibit lower frequency of nucleotide polymorphism than the untranscribed intergenic regions in the genomes of Escherichia coli and Salmonella enterica

This study compares polymorphism frequencies between transcribed and untranscribed intergenic regions in E. coli and S. enterica, finding that transcribed regions have lower polymorphism rates due to repair mechanisms and sequence features.

Synonymous polymorphism difference relating to codon degeneracy between co-transcribed genes in the genome of Escherichia coli

The paper compares synonymous polymorphism in co-transcribed gene pairs in E. coli operons, finding differences in mutation patterns related to codon degeneracy.

Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

This study identifies age-associated functional subpopulations of skeletal muscle macrophages using single-cell transcriptomics in mice.

Rheological transition driven by matrix makes cancer spheroids resilient under confinement

This study shows that ovarian cancer spheroids with an ECM coat (blastuloids) are more resilient under confinement than those without (moruloids) due to a rheological transition driven by the ECM-induced lumen.

Modified dN/dS for accounting transition and transversion frequency difference and non-sense substitution in genomes

The paper modifies the dN/dS ratio calculation to account for transition/transversion rate differences and non-sense substitutions, showing higher dN/dS values in E. coli and S. enterica genes.

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60.

This study shows persistent DNA damage alters lipid metabolism and histone acetylation via MYS-1/Tip60, leading to immune-like responses and age-related decline.

Bacterial hopanoids: a newly identified potent inducer of monocyte to macrophage differentiation

This study identifies bacterial hopanoids as a potent inducer of monocyte to macrophage differentiation through structural and functional analyses.

Delineating the complex mechanistic interplay between autophagy and monocyte to macrophage differentiation: a functional perspective

This study investigates the role of autophagy in monocyte to macrophage differentiation, showing its critical role in sustaining the process and directing differentiation via protein degradation.

Quantitative analysis and genome-scale modeling of human CD4+ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways

This study uses genome-scale modeling and lipidomics to show that glycosphingolipid pathways are specifically regulated in Th17 cells during differentiation and are critical for their effector functions.

Vortex chip incorporating an orthogonal turn for size-based isolation of circulating cells

The paper introduces a vortex chip with an orthogonal turn to isolate circulating cells based on size at lower flow velocities, demonstrating selective trapping of breast cancer cells in blood.

Highly accurate random DNA sequencing using inherent interlayer potential traps of bilayer MoS2 nanopores

This paper demonstrates high accuracy DNA sequencing using bilayer MoS2 nanopores, achieving ~90% accuracy in picomolar solutions with high signal-to-noise ratio.

3D micro-environment regulates NF-κβ dependent adhesion to induce monocyte differentiation

This paper shows that 3D gel-like micro-environments induce monocyte differentiation through adhesion-MAPK-NF-κβ feedback, challenging the idea that adhesion is a result of differentiation.