Two helices control the dynamic crosstalk between the catalytic domains of LRRK2
J.-H. Weng, P. C. Aoto, R. Lorenz, J. Wu, S. H. Schmidt, J. T. Manschwetus, P. Kaila-Sharma, S. Mathea, S. Knapp, F. W. Herberg, S. S. Taylor
The paper identifies two helices that regulate the conformation and function of the kinase domain in LRRK2 through dynamic crosstalk.
bioRxiv · Sep 29, 2021 · PreprintBiochemistry