Author

R. Penn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. D. Davidson· 1 shared B. Hanley· 1 shared D. A. Matthews· 1 shared D. H. Goldhill· 1 shared E. S. Giotis· 1 shared E. Staller· 1 shared J. A. Hassard· 1 shared J. C. Brown· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMicrobiology

A. D. Davidson

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2 papers

Recent·Most cited

Primary human macrophages exhibit a modest inflammatory response early in SARS-CoV-2 infection

Z. Zhang, R. Penn, W. S. S. Barclay, E. S. Giotis

This study shows that primary human macrophages do not support SARS-CoV-2 replication and exhibit a limited cytokine response, unlike influenza viruses which induce strong IFN-β and proinflammatory cytokines.

bioRxiv · Feb 2, 2022 · PreprintMicrobiology

The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells.

T. P. Peacock, D. H. Goldhill, J. Zhou, L. Baillon, R. Frise, O. C. Swann, R. Kugathasan, R. Penn, J. C. Brown, R. Y. Sanchez-David, L. Braga, M. K. Williamson, J. A. Hassard, E. Staller, B. Hanley, , W. S. Barclay

This study shows the furin cleavage site in SARS-CoV-2 spike protein enhances replication in airway cells, contributing to transmission efficiency.

bioRxiv · Sep 30, 2020 · PreprintMicrobiology