Author

R.A. Greenstein

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:statistical model· 3 Organism:yeast· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bassem Al‐SadyiD· 4 shared Sigurd J BrauniD· 3 shared Henry NgiD· 2 shared Ramón Ramos BarralesiD· 2 shared Andreas G. LadurneriD· 1 shared Andrew H. NgiD· 1 shared Catherine TaniD· 1 shared Eric C. SpiveyiD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersGenetics

Bassem Al‐SadyORCID

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Author profile →

5 papers

Recent·Most cited

Local chromatin context dictates the genetic determinants of the heterochromatin spreading reaction

R.A. Greenstein, Henry Ng, Ramón Ramos Barrales, Catherine Tan, Sigurd J Braun, Bassem Al‐Sady

The paper identifies gene regulators that influence heterochromatin spreading in different chromatin contexts using a fission yeast deletion library and sensor system.

PLoS Genetics · May 18, 2022Peer-reviewedMolecular Biology

The histone chaperone FACT facilitates heterochromatin spreading through regulation of histone turnover and H3K9 methylation states

Magdalena Murawska, R.A. Greenstein, Tamás Schauer, Karl C.F. Olsen, Henry Ng, Andreas G. Ladurner, Bassem Al‐Sady, Sigurd J Braun

This study identifies FACT as a histone chaperone that promotes heterochromatin spreading by regulating histone turnover and H3K9 methylation states.

Cell Reports · Nov 1, 2021Peer-reviewedGenetics

Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics

Susan Y. Chen, Lindsey C. Osimiri, Michael W. Chevalier, Lukasz J. Bugaj, Taylor H. Nguyen, R.A. Greenstein, Andrew H. Ng, Jacob Stewart-Ornstein, Lauren T. Neves, Hana El‐Samad

The paper introduces CLASP, an optogenetic tool to control TF localization, and shows differential promoter responses to pulsatile vs. continuous TF inputs.

Cell Systems · Sep 7, 2020Peer-reviewedSystems Biology

Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability

R.A. Greenstein, Ramón Ramos Barrales, Nicholas A. Sanchez, Jordan E. Bisanz, Sigurd J Braun, Bassem Al‐Sady

The paper identifies a mechanism by which Set1/COMPASS prevents heterochromatin invasion at euchromatic sites through inhibition of Suv39/Clr4 and disruption of nucleosome stability.

Genes & Development · Jan 1, 2020Peer-reviewedGenetics

A memory element imposes epigenetic behavior on intrinsically labile RNAi-induced heterochromatin spread.

R.A. Greenstein, Stephen K. Jones, Eric C. Spivey, James R. Rybarski, Ilya J. Finkelstein, Bassem Al‐Sady

The paper shows that RNAi-induced heterochromatin spread is stochastic, while a memory element called REIII provides deterministic, high-fidelity spreading in fission yeast.

eLife · Jul 18, 2018Peer-reviewedGenetics