Author

Rafael Rafailov

Stanford University

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Biophysics· 1

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Research Focus:benchmarking· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

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Ashir A. BorahiD· 1 shared Brian HieiD· 1 shared Claudia L. DriscolliD· 1 shared S. B. KingiD· 1 shared Talal WidatallaiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperBiophysics

Ashir A. BorahORCID

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1 paper

Recent·Most cited

Aligning protein generative models with experimental fitness via Direct Preference Optimization

Talal Widatalla, Ashir A. Borah, S. B. King, Claudia L. Driscoll, Rafael Rafailov, Brian Hie

This paper aligns a protein generative model with experimental fitness using Direct Preference Optimization, improving stability prediction and enabling new applications.

Nature Methods · Aug 14, 2026Peer-reviewedBiophysics