Rahul Kumar

TxCyto: A machine learning framework for estimating cytokine activity from whole transcriptome

A fully connected neural network trained on 9491 TCGA bulk tumor transcriptomes estimates activity of 645 cytokines and secreted proteins, checked against perturbation and protein data.

Extracellular protein catabolism drives regulated nitrogen handling and ammonia buffering in acute myeloid leukemia

This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.

Saturating hepatic clearance drives elevated cfDNA and fragment shortening in cancer

This study shows that elevated cfDNA and fragment shortening in cancer are due to saturated hepatic clearance, not tumor burden alone.