Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domain
Raza Haider, Brandon Shipley, Krystyna A. Surewicz, Michael Hinczewski, Witold K. Surewicz
This study investigates how phosphomimetic substitutions at C-terminal sites of TDP-43's low complexity domain alter liquid-liquid phase separation, revealing a biphasic salt dependence and changes in phase separation mechanisms.
Protein Science · Sep 20, 2024Peer-reviewedBiophysics