Latent Toxoplasma gondii infection increases soluble mutant huntingtin and promotes neurodegeneration in the YAC128 mouse model of Huntington's disease
David W. Donley, Teal Jenkins, Cailin S. Deiter, Reed Campbell, Marley Realing, Vanita Chopra, Stephen Hersch, Jason P. Gigley, Jonathan H. Fox
This study shows that latent Toxoplasma gondii infection worsens neurodegeneration in YAC128 HD mice by increasing soluble mutant huntingtin and neurofilament light protein levels.
bioRxiv · Feb 15, 2019 · PreprintNeuroscience