Author

Ria Sircar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Rajat RohatgiiD· 2 shared Andreas Sagner· 1 shared Andrew A. Morris· 1 shared Brian W. Bigger· 1 shared Cedric H. Shackleton· 1 shared Christian SieboldiD· 1 shared Douglas F Covey· 1 shared Eamon FX Byrne· 1 shared

Activity by Year

2016-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Rajat RohatgiORCID

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2 papers

Recent·Most cited

Bile Acid Biosynthesis Avoiding Cholesterol

William J. Griffiths, Jonas Abdel-Khalik, Peter J. Crick, Eylan Yutuc, Michael Ogundare, Brian W. Bigger, Andrew A. Morris, Cedric H. Shackleton, Peter T. Clayton, Takashi Iida, Ria Sircar, Hanns-Ulrich Marschall, Jan Sjövall, Ingemar Björkhem, Rajat Rohatgi, Yuqin Wang

The paper identifies a novel bile acid biosynthesis pathway in Smith-Lemli-Opitz syndrome that bypasses cholesterol, starting from 7-dehydrocholesterol, and links intermediates to Hedgehog signaling.

bioRxiv · Aug 5, 2018 · PreprintBiochemistry

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon FX Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi

The paper shows cholesterol directly activates the GPCR Smoothened to drive Hedgehog signaling by binding its extracellular domain, independent of traditional GPCR mechanisms.

eLife · Oct 5, 2016Peer-reviewedDevelopmental Biology