Developmental BiologyeLifePeer-reviewed
Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling
Giovanni Luchetti, Ria Sircar, Jennifer H Kong…·Rajat Rohatgi
The paper shows cholesterol directly activates the GPCR Smoothened to drive Hedgehog signaling by binding its extracellular domain, independent of traditional GPCR mechanisms.
DOI 10.7554/elife.20304