Author

Ricky Siebeler

Amsterdam UMC Location University of Amsterdam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Menno P.J. de WintheriD· 2 shared Agnieszka Witalisz‐SieprackaiD· 1 shared Alexandra DrakakiiD· 1 shared Bruno GuigasiD· 1 shared Cindy P. A. A. van Roomen· 1 shared Coen C. PaulusmaiD· 1 shared Dagmar StoiberiD· 1 shared Dirk Rudi de WaartiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Menno P.J. de WintherORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Increasing plasma bile salt levels with Bulevirtide alleviates DSS-induced colitis and LPS-induced inflammation

Thuc-Anh Nguyen, Reinout L.P. Roscam Abbing, Pim J. Koelink, Joost M. Lambooij, Wietse In het Panhuis, Dirk Rudi de Waart, Isabelle Bolt, Suzanne Duijst, Esther W.M. Vogels, Ricky Siebeler, Menno P.J. de Winther, Bruno Guigas, Manon E. Wildenberg, Coen C. Paulusma, Stan F.J. van de Graaf

This study shows that Bulevirtide increases plasma bile salt levels in mice, reducing inflammation in LPS-induced models and DSS-induced colitis.

bioRxiv · Apr 23, 2026 · PreprintImmunology

A CROP-seq screen of histone modifying enzymes reveals histone demethylase Kdm5c regulates inflammatory macrophage activation.

Femke Horstman, Guillermo R. Griffith, Francesco Vinciguerra, Ricky Siebeler, Cindy P. A. A. van Roomen, Tatyana Kuznetsova, Judith C. Sluimer, Gerard Pasterkamp, Michal Mokrý, Menno P.J. de Winther, Koen H.M. Prange

The paper uses CROP-seq to identify histone modifying enzymes regulating inflammatory macrophage activation, finding Kdm5c modulates inflammatory responses by balancing baseline and inducible activation.

bioRxiv · Oct 30, 2025 · PreprintMolecular Biology

Uncovering an unconventional JAK1/2-STAT3 branch in macrophage IFNγ signaling

Mees Botman, Josje M.A. Huisman, Alexandra Drakaki, Sanne Lidewij Maas, Agnieszka Witalisz‐Siepracka, Dagmar Stoiber, Emiel P. C. van der Vorst, Ricky Siebeler, Marten A. Hoeksema

The paper identifies an unconventional JAK1/2-STAT3 signaling pathway in macrophage IFNγ responses, showing STAT3 activation and heterodimerization with STAT1, but limited gene regulatory contribution.

bioRxiv · Aug 13, 2025 · PreprintImmunology