Chronic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver
Manoj Kumar Singh, Rijith Jayarajan, Swati Varshney, Sindhuri Upadrasta, Archana Kumari Singh, Rajni Yadav, Vinod Scaria, Shantanu Sengupta, Dhanasekaran Shanmugam, S. Shalimar, Sridhar Sivasubbu, Sheetal Gandotra, Chetana Sachidanandan
This study shows chronic IL6 overexpression in zebrafish causes liver fat accumulation through glycolysis deregulation, suggesting inflammation as a cause for obesity-independent NAFLD.
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · Feb 15, 2021Peer-reviewedMolecular Biology