Reprogramming tumour-associated macrophages from immune suppressive to inflammatory state by Checkpoint kinase 1 inhibitor combination treatment
Zhen Zeng, Anastasia Gandini, Ritu Bhatt, Martina A. Proctor, Jintao Guo, Susan Marie Millard, Sherry Y. Wu, Riccardo Dolcetti, James W. Wells, Jazmina L. Gonzalez Cruz, Katharine M. Irvine, Brian G. Gabrielli
This study shows that CHK1i+LDHU reprograms tumour-associated macrophages to an inflammatory state while preserving immunosuppressive features, enhancing CD8 T cell activation and therapeutic efficacy.
bioRxiv · May 17, 2026 · PreprintCancer Biology