Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
Sarah Dobner, Lisa Kleißl, Fanni Tóth, Robert L. Paxton, Irena Yordanova, Kveta Brazdilova, Cedric Vanluyten, Aleksandra Aizenshtadt, Hanna Toth, Jake Burton, Aglaja Kopf, Vera Belyaeva, Katharina Ferencevic, Dunja Al‐Nuaimi, André F. Rendeiro, , Laura P. M. H. de Rooij
This study creates a comprehensive single-cell transcriptomic atlas of human endothelial cells across adult life, identifying age-related transcriptional changes and a p21-linked senescence program.
bioRxiv · Aug 18, 2025 · PreprintCell Biology