Abdel Rahman Abdel Fattah

This study creates a comprehensive single-cell transcriptomic atlas of human endothelial cells across adult life, identifying age-related transcriptional changes and a p21-linked senescence program.

This study reveals how CCM2-silenced endothelial cells use mechanical forces to recruit and reprogram wild-type cells, driving vascular lesion growth through force-guided invasion and cellular reprogramming.

This paper introduces a method to locally actuate organoids using magnetic nanoparticles, enabling precise mechanical perturbations and enhanced patterning in neural and mesoderm organoids.

The paper demonstrates that Wnt-driven Turing mechanisms mediate neuroepithelial organoid patterning through in silico modeling and scRNA-seq analysis.