Reprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes
Ellen Y. Zhang, Sang Hyun Lee, Yu‐Chung Liu, Yuna Heo, Hannah Hyun-Sook Kim, D K Kim, Tyler E. Blanch, Jaeun Jung, Claudia Loebel, Melike Lakadamyali, Robert Mauck, Inkyung Jung, Su‐Jin Heo
This study identifies chromatin stability as critical for preserving chondrocyte function during expansion and shows that Fludarabine maintains phenotype by stabilizing chromatin and reducing STAT1 activity.
bioRxiv · May 13, 2026 · PreprintBioengineering