Claudia Loebel

This study uses a magnetoactive hydrogel to investigate how curvature affects endothelial cell mechanosensing, finding that curvature influences YAP localization and junctional dynamics independently of shear stress.

This study shows that hydrogel dimensionality affects how tendon fibroblasts respond to mechanical cues, altering nascent matrix deposition.

The paper shows that nascent extracellular matrix converts hydrogel chemical cues into cell fate decisions, with low modification promoting differentiation and high modification promoting proliferation.

This study identifies decorin-mediated extracellular matrix stabilization as a key factor in maintaining cartilage integrity during aging, showing its role in preventing age-associated osteoarthritis.

The paper constructs a developmental cell atlas of the human esophagus and develops in vitro models that recapitulate esophageal architecture, revealing WNT2B's role in regulating basal progenitor self-renewal.

This study shows that the postnatal tendon enthesis remains hypoxic and requires Hif1a for cell survival, ECM organization, and structural integrity.

This study identifies chromatin stability as critical for preserving chondrocyte function during expansion and shows that Fludarabine maintains phenotype by stabilizing chromatin and reducing STAT1 activity.

This study shows that mechanical and hormonal cues regulate ECM deposition by endometrial stromal cells during decidualization.

This study uses photo-crosslinking to induce early fibrotic changes in ex vivo tissue, showing how matrix stiffening affects cell behavior and fibrosis progression.

This study shows that high-viscosity hydrogels lead to increased nascent extracellular matrix deposition by cells, independent of intracellular contractility.

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

This study develops a Matrigel-free method using synthetic hydrogels to form alveolar organoids, showing they secrete their own extracellular matrix for growth.

This study quantifies matrix deposition by muscle stem cells during activation using engineered hydrogels and shows it is critical for maintaining stem cell function.

The paper identifies EPIREGULIN as a niche factor that enables spatial organization in human intestinal organoids, mimicking the native intestine's structure and gene expression.