Author

Roberto Miguez

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Elizabeth M.H. TankiD· 2 shared Nicolás GómeziD· 2 shared Sami J. BarmadaiD· 2 shared Andrea SerioiD· 1 shared Carmen Moreno-GonzaleziD· 1 shared Caroline Hsieh· 1 shared Jemeen SreedharaniD· 1 shared Jonathon P. McBrideiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Elizabeth M.H. TankORCID

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2 papers

Recent·Most cited

RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia

Michael McMillan, Nicolás Gómez, Caroline Hsieh, Michael E. Bekier, Xingli Li, Roberto Miguez, Elizabeth M.H. Tank, Sami J. Barmada

This study shows that RNA methylation influences TDP43 binding and contributes to neurodegeneration in ALS by modulating RNA stability and TDP43 function.

Molecular Cell · Jan 1, 2023Peer-reviewedNeuroscience

Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS

Kaitlin Weskamp, Elizabeth M.H. Tank, Roberto Miguez, Jonathon P. McBride, Nicolás Gómez, Matthew A. White, Ziqiang Lin, Carmen Moreno-Gonzalez, Andrea Serio, Jemeen Sreedharan, Sami J. Barmada

This study shows that shortened TDP43 isoforms, upregulated by neuronal hyperactivity, drive TDP43 pathology in ALS by forming cytoplasmic inclusions and sequestering full-length TDP43.

Journal of Clinical Investigation · Nov 12, 2019Peer-reviewedNeuroscience