Direct NMR evidence for transient binding of the vesicular SNARE protein synaptobrevin-2/VAMP2 to the α-synuclein C-terminus
Sophia Werner, Tobias Stief, Celina M Schulz, Katharina Vormann, Robin Backer, Marie P Schutzmann, Lothar Gremer, Wolfgang Hoyer, Nils-Alexander Lakomek
This study provides direct evidence of transient binding between α-synuclein C-terminus and synaptobrevin-2 using NMR and other biophysical methods, suggesting a role in neuronal exocytosis.
bioRxiv · Nov 4, 2026 · PreprintBiophysics