PSMD14 drives melanoma cell survival and MAPK inhibitor resistance through histone H2A deubiquitination
Michael Ohanna, Pierric Biber, Mira Kahil, Serena Diazzi, Lauren Lefevre, Frédéric Larbret, Robin Didier, Stéphane Audebert, Véronique Delmas, Lionel Larue, Sophie Tartare‐Deckert, Marcel Deckert
This study identifies PSMD14 as a key driver of melanoma survival and resistance to MAPK inhibitors by deubiquitinating histone H2A, altering chromatin state and gene expression.
bioRxiv · Mar 2, 2026 · PreprintCancer Biology