Autophagy Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in Glioma
Shahla Shojaei, Amir Barzegar Behrooz, Kianoosh Naghibzadeh, João Luiz Martins Basso, Javad Alizadeh, Tania Dehesh, Roham Saberi, Bhavya Bhushan, Mehdi Eshraghi, Simone CDS Rosa, Courtney Jessica Clark, Mateusz M. Tomczyk, Laura Cole, Grant Michael Hatch, Vernon Wayne Dolinsky, , Saeid Ghavami
This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.
bioRxiv · Jan 20, 2026 · PreprintCancer Biology