Deconvolution of Sample Identity in Single-Cell RNA Sequencing via Genome Imputation
Rohit Ghosh, Rupert Hugh-White, Farshad Nassiri, Gelareh Mohammed Zadeh, Paul Christopher Boutros
The paper introduces a method to assign single-cell RNA-seq data to donor-of-origin without prior genetic information, achieving high concordance in tumor-derived data.
bioRxiv · Feb 11, 2025 · PreprintBioinformatics