Hydroxychloroquine decouples reactogenicity from efficacy in mRNA and viral-vector gene delivery
Duško Lainšček, Špela Malenšek, Anja Golob-Urbanc, Sara Orehek, Jure Bohinc, Mateja Manček Keber, Timotej Sotošek, Hana Esih, Vida Forstnerič, Peter Pečan, Jelica Pantović-Žalig, Mojca Benčina, Romina Bester, Ulrike Protzer, Roman Jerala
This study shows hydroxychloroquine reduces inflammation from mRNA and viral-vector therapies without affecting their therapeutic effectiveness.
bioRxiv · Nov 10, 2025 · PreprintImmunology