Spatially-resolved multimodal profiling identifies functionally-heterogeneous cancer-associated fibroblasts associated with poor radiotherapy outcomes in muscle-invasive bladder cancer.
Amy Burley, Katie O’Fee, Morgane Dromby, Mi Chween Chan, Barry A. Gusterson, Adrian Lärkeryd, Emma Westlund, Priya Narayanan, Chirine Sakr, Tatiany Silveira, Rose Foster, Mikel Portillo, Marc Rabionet Diaz, Tom Lund, Alan A. Melcher, , Anna Clare Wilkins
This study identifies functionally heterogeneous cancer-associated fibroblasts in muscle-invasive bladder cancer linked to poor radiotherapy outcomes.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology