Genomic and Transcriptomic Landscapes of MEN1-Wild-Type Low-Grade Metastatic Pancreatic NETs Uncover Key Oncogenic Drivers and Targetable Pathways
Md. Hafiz Uddin, Zaid K Mahdi, Irfana Muqbil, Brendon Herring, Rose J. Bart, Husain Yar Khan, Yiwei Li, Amro Aboukameel, Sahar F. Bannoura, Hugo Jimenez, Allan M. Johansen, Mohammad Najeeb Al-Hallak, Ibrahim Hanna Azar, Amr Mohamed, Tarik H. Hadid, , Asfar S. Azmi
This study identifies key oncogenic pathways and targetable genes in MEN1-wild-type low-grade pancreatic NETs that drive metastasis, offering a therapeutic strategy based on pathway intensity rather than mutation count.
International Journal of Biological Sciences · Sep 3, 2026Peer-reviewedCancer Biology