IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum
Francesca Zappa, Advait Subramanian, Benjamin Yang, Julia E. Conrad, Tsan‐Wen Lu, Jing Wang, Nicolas A. DeBeaubien, Rose Yan, Renato Minopoli, Tristan Ian Croll, Stefka Tyanova, Mauro Costa‐Mattioli, Peter Walter, Diego Acosta‐Alvear
The paper identifies a third mode of IRE1 activation called TRES, triggered by reduced protein influx into the ER, leading to a distinct gene expression program to rebalance ER load.
bioRxiv · Mar 9, 2026 · PreprintCell Biology