Jing Wang

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus

This paper develops a computational model of the parkinsonian subthalamic nucleus showing how synchronized bursting produces beta-HFO coupling and explains HFO frequency shifts.

Oncolytic Newcastle disease virus promotes tumor cell apoptosis through SUMO-1-dependent PRKN-mediated degradation of c-Myc

Fast Generalized Longitudinal Functional Principal Components Analysis with Applications to Population-Level Neuronal Dynamics

This paper introduces a fast generalized LFPCA method for analyzing longitudinal functional data, showing it is faster and scalable while applied to neuronal firing rate data under DBS.

PlantGeneAnn: a high-accuracy ab initio plant gene annotation tool fine-tuned from a genome foundation model

PlantGeneAnn is a plant-optimized gene annotation tool that outperforms existing methods on a 20-species benchmark and enables efficient fine-tuning for non-model species.

Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

Cooperative Peripheral CB1 Inhibition by Extracellular Antibody Binding and Orthosteric Antagonism

This study reports cryo-EM structures of CB1 bound to Nimacimab and orthosteric antagonists, revealing extracellular allosteric inhibition as a mechanism for peripheral CB1 inhibition.

Spontaneous eye behavior is an objective marker of parkinsonian severity

The paper shows that spontaneous eye behavior in a nonhuman primate PD model correlates with disease severity and beta oscillatory activity, suggesting it as a potential biomarker.

Multi-kingdom microbial diversity and interaction landscapes in mosquitoes revealed by 5,163 individual meta-transcriptomes

The paper analyzes 5,163 mosquito meta-transcriptomes to characterize microbial diversity and interactions, identifying pathogens and cross-kingdom associations.

The Maine Coon Cat Harboring the MYBPC3-A31P Mutation: A Genotype-Stratified Phenotypic Characterization of Hypertrophic Cardiomyopathy

This study characterizes the phenotypic effects of MYBPC3-A31P mutation in Maine Coon cats, showing gene-dose effects on cardiac structure and function, with homozygous cats exhibiting more severe features.

Extracellular vesicle-mediated suppression of macrophage STING signaling promotes immune dysfunction in dedifferentiated liposarcoma

This study shows that extracellular vesicles from dedifferentiated liposarcoma suppress macrophage STING signaling, leading to immune dysfunction and poor response to immunotherapy.

Progerin-Induced Nuclear Envelope Remodeling is Shaped by Cell Division and NUP153

This study shows progerin causes nuclear envelope remodeling in two stages, with NUP153 promoting invagination, and links these changes to aging-related nuclear morphology.

NEURA: A proof-carrying framework for hallucination-resistant neuroimaging automation

NEURA automates neuroimaging workflows using a proof-carrying framework to reduce hallucination, achieving high accuracy and detecting injected errors in controlled experiments.

Integrin beta 4 promotes colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin signaling pathway

This study identifies ITGB4 as a driver of colorectal cancer progression by upregulating Ezrin and activating the Wnt/β-catenin pathway.

3'UTR Insertion of a Directed-Evolved RNA Element for Enhanced Translation

This paper identifies RNA elements in the 3'UTR that enhance translation efficiency across multiple systems.

Structure-guided reinterpretation of a disease-associated CWH43 residue-533 truncation identifies internal disruption of a conserved C-terminal module in idiopathic normal pressure hydrocephalus

The paper reinterprets a CWH43 truncation variant in iNPH using structural analysis, showing it disrupts a conserved C-terminal module and cavity architecture.

Parkinsonism disrupts the population-level organization of cortical dynamics

This study investigates how parkinsonism alters population-level neural activity in M1 during movement, finding increased dimensionality and reduced orthogonality between preparatory and movement-related subspaces.

The world's first cloned golden wild yak via interspecific SCNT: 4800m donor origin and 4200m vitrified blastocyst transfer

This paper reports the first successful cloning of a golden wild yak using interspecific somatic cell nuclear transfer under extreme high-altitude conditions.

A genome-wide CRISPR Screening identifies targets that drive Tolerogenic Dendritic Cells

This study uses CRISPR screening to identify molecular targets that drive the function of tolerogenic dendritic cells, revealing CD86 and UBE2L6 as key regulators of immune tolerance.

Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure

This study identifies a compound that inhibits RhoA activation by stabilizing its GDP state, reducing myocardial remodeling and fibrosis in heart failure models.

IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum

The paper identifies a third mode of IRE1 activation called TRES, triggered by reduced protein influx into the ER, leading to a distinct gene expression program to rebalance ER load.

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Evaluation of visual performance for RCS rats: A tailor-made OMR setup via DeepLabCut and PsychoPy with a customized algorithm

This study develops a tailored OMR setup for RCS rats using DeepLabCut and PsychoPy, finding normal OMR at P30/P50 but significant decline in older RCS rats indicating blindness.

DEMINERS enables clinical metagenomics and comparative transcriptomic analysis by increasing throughput and accuracy of nanopore direct RNA sequencing

Tibicos differentially affects faecal microbiota composition and short-chain fatty acid production in prediabetic and healthy adults in a simulated digestive tract

This study examines how ginger-cayenne tibicos affects faecal microbiota and SCFA production in prediabetic and healthy adults using an in vitro model.

ORMDL3 restrains type-I interferon signaling and anti-tumor immunity by promoting RIG-I degradation

This study identifies ORMDL3 as a negative regulator of type-I interferon signaling by promoting RIG-I degradation, which impacts anti-tumor immunity.

Resolving somatic SVs via full-length sequence model-based local graph-genome optimization

SVscope improves somatic SV detection using full-length sequence models and local graph-genome optimization, achieving higher accuracy than existing methods.

Infectome analysis of bat kidneys from Yunnan province, China, reveals close relatives of Hendra-Nipah viruses and prevalent bacterial and eukaryotic pathogens

The paper analyzes the infectome of bat kidneys from Yunnan, China, identifying novel viruses, a protozoan parasite, and bacterial species, including henipaviruses related to Hendra and Nipah viruses.

Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife

The paper analyzes wildlife infectomes to identify zoonotic pathogens, finding 62 novel pathogens including a new coronavirus genus and highlighting high pathogen diversity in Carnivora and Rodentia.

Omicron-specific naive B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

The paper investigates how Omicron-specific naive B cell maturation after breakthrough infection alleviates immune imprinting from inactivated SARS-CoV-2 vaccines.

From Sight to Insight: A Multi-task Approach with the Visual Language Decoding Model

This paper introduces a Visual Language Decoding Model (VLDM) that simultaneously decodes visual categories, semantic labels, and textual descriptions from neural data, achieving significant improvements over chance levels.