Neogenin-1 marks myeloid-primed fetal hematopoietic stem cells that undergo progressive lineage-restriction with age
Allison M. Banuelos, Michelle Baez, Leyla Yılmaz, Elle Koren, Monika Żukowska, Andrew T. Burden, Leah Swartzrock, Uyen Le, Allison Zhang, Benjamin F Ohene-Gambill, Nardin Georgeos, Bowen Zheng, Nicole L. Womack-Gambrel, Ruby Honjol, Rahul Sinha, Irving L. Weissman
The paper identifies Neogenin-1 as a marker for myeloid-biased fetal HSCs and shows that lineage bias is established early and reinforced with age.
bioRxiv · Sep 3, 2026 · PreprintDevelopmental Biology