Regulation of the human voltage-gated proton channel by membrane sterols
Shuo Han, Rui Duan, Sarah Applewhite, Shuyi Wang, Grace Wang, Mingxing Qian, Douglas F. Covey, Xiaoqin Zou, Shizhen Wang
This study investigates how cholesterol and its analogs regulate the hHv1 proton channel by altering S4 segment conformation, identifying key residues and mechanisms involved.
bioRxiv · Aug 22, 2026 · PreprintBiophysics