Ryan A. Moon

Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy

This study shows that impaired BCAA metabolism promotes ferroptosis, leading to pulmonary arterial hypertension and associated liver disease, and that targeting BCAA metabolism can alleviate these effects.

Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV Dysfunction

This study uses multi-omics profiling to identify molecular mechanisms contributing to progressive right ventricular dysfunction in pigs.

Lactobacillus Restructures the Micro/Mycobiome to Combat Glycoprotein-130 Associated Microtubule Remodeling and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

This study shows Lactobacillus modulates the gut microbiome to reduce inflammation and improve RV function in PAH by counteracting GP130-mediated microtubule remodeling.

Proteomic and Metabolomic Profiling Nominates Druggable Targets and Biomarkers forPulmonary Arterial Hypertension-Associated Myopathy and Exercise Intolerance

The paper identifies differential metabolic and proteomic changes in skeletal muscles of PAH rats and suggests mitochondrial biogenesis and proteasome activation as potential therapeutic targets.

Multi-omic Evaluations Nominate an ER-Mitochondrial Axis and Inflammatory Macrophage as Drivers of Right Atrial Dysfunction

This study identifies ER-mitochondrial dysfunction and inflammatory macrophages as drivers of right atrial dysfunction using multi-omic analyses in a pulmonary artery banded swine model.

17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function

This study shows 17β-estradiol counteracts pathological microtubule remodeling in cardiomyocytes, improving cardiac function and preventing cellular hypertrophy and structural abnormalities.

Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded Pigs

SC144 improves right ventricular function in pulmonary artery banded pigs by reducing inflammation, restoring metabolism, and enhancing cell communication.