Author

Ryan Denniston

Douglas Mental Health University Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anjali ChawlaiD· 2 shared Gustavo TureckiiD· 2 shared Maria Antonietta DavoliiD· 2 shared Naguib MechawariD· 2 shared Reza RahimianiD· 2 shared Volodymyr YerkoiD· 2 shared Angelina Morgan· 1 shared Clare C Austin· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersNeuroscience

Anjali ChawlaORCID

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3 papers

Recent·Most cited

Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse

Marina Wakid, Daniel Almeida, Ryan Denniston, Anjali Chawla, Zahia Aouabed, Maria Antonietta Davoli, Kristin Ellerbeck, Reza Rahimian, Volodymyr Yerko, Elena Leonova-Erko, Gustavo Turecki, Naguib Mechawar

This study identifies widespread gene expression changes in the neurovascular unit of female depressed suicides with childhood abuse histories, highlighting key regulators like KLF2 and KLF4.

Molecular Psychiatry · Oct 30, 2025Peer-reviewedNeuroscience

Differential Chromatin Architecture and Risk Variants in Deep Layer Excitatory Neurons and Grey Matter Microglia Contribute to Major Depressive Disorder

Anjali Chawla, Doruk Cakmakci, Laura M. Fiori, Wenmin Zang, Malosree Maitra, Jennie Yang, Dariusz Żurawek, Gabriella Frosi, Reza Rahimian, Haruka Mitsuhashi, Maria Antonietta Davoli, Ryan Denniston, Gary Gang Chen, Volodymyr Yerko, Deborah C. Mash, , Gustavo Turecki

This study identifies differential chromatin architecture and risk variants in specific brain cell types associated with major depressive disorder.

Nature Genetics · Aug 1, 2025Peer-reviewedGenomics

The RNA binding proteins Ddx6 and Ddx61 support development in mRNA-decay deficient pnrc2 mutants

Thomas L. Gallagher, Monica C. Blatnik, Clare C Austin, Kathryn G Thompson, Danielle M Pvirre, Ryan Denniston, Angelina Morgan, Michael G. Kearse, Sharon L. Amacher

The paper shows that Ddx6 and Ddx61 compensate for mRNA decay defects in pnrc2 mutants by regulating translation and poly(A) tail length.

bioRxiv · May 8, 2025 · PreprintDevelopmental Biology