NLRP3 is a thermosensor that is negatively regulated by high temperature
Wei Wang, Damien Bertheloot, Junya Zhang, Marcia A. Munoz, Shangze Xu, Amelia Stennett, Chloe M. McKee, Ryan Knight, Emma C. McKay, Bernardo S. Franklin, Michael J. Rogers, Agnieszka K. Bronowska, Rebecca C. Coll
This study shows high temperatures inhibit NLRP3 inflammasome activation, identifying NLRP3 as a thermosensor and revealing a temperature-sensitive conformational change in its C-terminal domain.
bioRxiv · Sep 29, 2025 · PreprintImmunology