TRPML1 signaling at lysosomes-mitochondria nexus drives triple-negative breast cancer mitophagy, metabolic reprogramming and chemoresistance
Alia Kazim Rizvi Syeda, Shekoufeh Almasi, Cory J. Benson, Barry E. Kennedy, Ryan M. Yoast, Scott M. Emrich, Logan Slade, Shanmugasundaram Pakkiriswami, Vishnu Vijay Vijayan, Shashi Ashok Gujar, Thomas Pulinilkunnil, Mohamed Trebak, Yassine El Hiani
This study identifies TRPML1 as a key regulator of mitochondrial function and chemoresistance in TNBC by modulating lysosomal-mitochondria signaling and autophagy.
bioRxiv · Sep 11, 2025 · PreprintCancer Biology