Mohamed Trebak

This study shows that endothelial calcium signaling spreads widely during vascular injury, but phosphatidylserine externalization remains localized, revealing spatial uncoupling between calcium signaling and phospholipid scrambling.

The paper compares the ability of different Orai isoforms to promote NFAT activation and transcription, finding Orai1α and Orai1β are more potent than Orai2 and Orai3.

This study investigates calcium signaling in Schistosoma mansoni by analyzing STIM and ORAI proteins, identifying pharmacological differences that could enable selective targeting of schistosome calcium channels.

This study identifies RHOV as a detachment-sensitive Rho GTPase critical for ovarian cancer peritoneal metastasis by enhancing anoikis resistance and cytoskeletal remodeling.

This paper identifies CYB5R3 as a redox switch that couples store-operated calcium entry to TRPV2 activation, enhancing vascular function through NO-dependent oxidative inhibition of PTPN1.

This study identifies TRPML1 as a key regulator of mitochondrial function and chemoresistance in TNBC by modulating lysosomal-mitochondria signaling and autophagy.

The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.

This study shows that loss of STIM2 in colorectal cancer promotes tumor growth and metastasis through metabolic reprogramming and activation of the PERK-ATF4 ER stress pathway.

This study identifies B cell-intrinsic and -extrinsic mechanisms by which IRF7 promotes spontaneous autoimmune germinal center and plasma cell responses, autoantibody production, and SLE development.

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.