Tricuspid valve regurgitation accelerates heart failure via a cardio-intestinal innate immune circuit
Florian Sicklinger, Tobias Thiemann, Sarah Rupprecht, Lisa Quadt, Junedh Amrute, Jan Zuchgan, Jakob Christoph Voran, George Markousis‐Mavrogenis, Alejandra Isasi Nalvarte, Laura M. Wienecke, Niklas Hartmann, S Erbe, Isabel A. Hoerbrand, Martin Kraus, Martin J. Gruber, , Florian Leuschner
This study identifies a cardio-intestinal innate immune circuit driven by tricuspid valve regurgitation that promotes heart failure through IL-6-mediated myocardial fibrosis and dysfunction.
bioRxiv · Jul 11, 2026 · PreprintImmunology