The mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress
S. Backes, Y. S. Bykov, M. Raeschle, J. Zhou, S. Lenhard, L. Kraemer, T. Muehlhaus, C. Bibi, C. Jann, J. D. Smith, L. M. Steinmetz, D. Rapaport, Z. Storchova, M. Schuldiner, F. Boos, J. M. Herrmann
The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.
bioRxiv · Sep 14, 2020Cell Biology