D. Rapaport

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

Characterization of Tgl2, a putative lipase in yeast mitochondria

This study characterizes Tgl2, a putative TAG lipase in yeast mitochondria, showing its dimerization, catalytic residues, and role in mitochondrial lipid homeostasis.

Mpf1 is a novel factor that affects the dual distribution of tail-anchored proteins between mitochondria and peroxisomes

This study identifies Mpf1 as a novel factor influencing the dual targeting of tail-anchored proteins between mitochondria and peroxisomes in yeast.

A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins

This study identifies cytosolic (co)chaperones that interact with signal-anchored mitochondrial proteins and facilitate their biogenesis.

Dissecting the interactions of PINK1 with the TOM complex in depolarized mitochondria

This study investigates how PINK1 interacts with the TOM complex in depolarized mitochondria, revealing the role of TOM70 and TOM40 in its association with the mitochondrial outer membrane.

A unified model for the biogenesis of mitochondrial outer membrane multi-span proteins

This study investigates the biogenesis of mitochondrial outer membrane multi-span proteins using yeast and Om14, showing that both protein factors and membrane properties influence their integration.

The mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.

Structural basis of client specificity in mitochondrial membrane-protein chaperones

The paper determines how two mitochondrial chaperones bind different membrane proteins by analyzing their structural interactions and identifies factors that influence client specificity.