Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding.
S. Bertini, A. Alekseeva, S. Elli, I. Pagani, S. Zanzoni, G. Eisele, R. Krishnan, K. P. Maag, C. Reiter, D. Lenhart, R. Gruber, E. A. Yates, E. Vicenzi, A. Naggi, A. Bisio, M. Guerrini
This study shows that pentosan polysulfate inhibits SARS-CoV-2 attachment and infection in vitro, with effectiveness comparable to heparin and better than low molecular weight heparin.
bioRxiv · Dec 19, 2021 · PreprintBiochemistry