Author

E. A. Yates

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. E. Turnbull· 4 shared M. A. Skidmore· 4 shared A. Cartmell· 3 shared D. P. Byrne· 3 shared M. Guerrini· 3 shared S. E. Guimond· 3 shared A. Basle· 2 shared A. S. Luis· 2 shared

Activity by Year

2019-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiochemistry

J. E. Turnbull

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Author profile →

10 papers

Recent·Most cited

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment

A. L. Gray, R. Karlsson, A. R. Roberts, A. J. Ridley, N. Pun, C. Hughes, L. Medina-Ruiz, H. Birchenough, C. Salanga, E. A. Yates, J. E. Turnbull, T. M. Handel, G. Graham, T. A. Jowitt, I. Schiessl, , D. P. Dyer

The paper shows CXCL4 binds to extracellular matrix proteoglycans, increasing vascular permeability and recruiting various leukocytes through a non-canonical mechanism.

bioRxiv · Jul 10, 2022 · PreprintImmunology

Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding.

S. Bertini, A. Alekseeva, S. Elli, I. Pagani, S. Zanzoni, G. Eisele, R. Krishnan, K. P. Maag, C. Reiter, D. Lenhart, R. Gruber, E. A. Yates, E. Vicenzi, A. Naggi, A. Bisio, M. Guerrini

This study shows that pentosan polysulfate inhibits SARS-CoV-2 attachment and infection in vitro, with effectiveness comparable to heparin and better than low molecular weight heparin.

bioRxiv · Dec 19, 2021 · PreprintBiochemistry

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota

A. S. Luis, A. Basle, D. P. Byrne, G. S. Wright, J. London, J. Chunsheng, N. Karlsson, G. C. Hansson, P. A. Eyers, M. Czjzek, T. Barbeyron, E. A. Yates, E. C. Martens, A. Cartmell

This study analyzes carbohydrate sulfatases from Bacteroides thetaiotaomicron, correlating structural and functional data with phylogenetic and environmental analyses to understand sulfated glycan metabolism.

bioRxiv · Jul 23, 2021Biochemistry

Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells

I. Pagani, L. Ottoboni, P. Podini, S. Ghezzi, E. Brambilla, S. Bezukladova, D. Corti, M. E. Bianchi, M. R. Capobianchi, E. A. Yates, G. Martino, E. Vicenzi

bioRxiv · May 5, 2021 · PreprintMicrobiology

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity.

D. P. Byrne, J. A. London, P. A. Eyers, E. A. Yates, A. Cartmell

This study develops a rapid capillary electrophoresis assay for quantifying carbohydrate desulfation by sulfatases, demonstrating its advantages over existing methods.

bioRxiv · Dec 1, 2020Biochemistry

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium

A. S. Luis, C. Jin, G. Vasconcelos Pereira, R. W. P. Glowacki, S. Gugel, S. Singh, D. P. Byrne, N. A. Pudlo, J. A. London, A. Basle, M. Reihill, S. Oscarson, P. Eyers, M. Czjzek, G. Michel, , E. C. Martens

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

bioRxiv · Nov 20, 2020 · PreprintMicrobiology

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

S. E. Guimond, C. J. Mycroft-West, N. S. Gandhi, J. A. Tree, T. T. Le, C. M. Spalluto, M. V. Humbert, K. R. Buttigieg, N. Coombes, M. J. Elmore, K. Nystrom, J. Said, Y. X. Setoh, A. Amarilla, N. Modhiran, , J. E. Turnbull

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

bioRxiv · Jun 24, 2020Microbiology

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.

C. J. Mycroft-West, D. Su, S. Elli, Y. Li, S. E. Guimond, G. J. Miller, J. E. Turnbull, E. A. Yates, M. Guerrini, D. G. Fernig, M. Andrade de Lima, M. A. Skidmore

The paper shows that SARS-CoV-2 Spike S1 RBD undergoes a conformational change when bound to heparin, suggesting potential for heparin as a therapeutic.

bioRxiv · Feb 29, 2020 · PreprintBiochemistry

High sensitivity (zeptomole) detection of BODIPY heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts.

M. L. Maciej-Hulme, A. C. Leprince, A. Lavin, S. E. Guimond, J. E. Turnbull, J. Pelletier, E. A. Yates, A. K. Powell, M. A. Skidmore

This paper develops a highly sensitive method to detect BODIPY-labeled HS disaccharides, enabling analysis of HS from small biological samples like mosquito midguts.

bioRxiv · Jan 21, 2020 · PreprintBiochemistry

Using ATR-FTIR spectroscopy to characterise crude heparin samples by composition and structural features.

A. J. Devlin, L. Mauri, M. Guerrini, E. A. Yates, M. A. Skidmore

This paper uses ATR-FTIR spectroscopy with chemometric analysis to characterize crude heparin samples by composition and structural features, enabling quality control during production.

bioRxiv · Aug 22, 2019 · PreprintBiochemistry